Views on Polygenic Screening

Angela

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Public views on polygenic screening of embryos | Science

"[FONT=&quot]For decades, people have used genetic information to exercise control over the kinds of children they will have. These technologies have largely targeted chromosomal and monogenic disorders and traits; but most human phenotypes are highly polygenic (and influenced by the environment). One technology that targets the entire genome—preimplantation genetic testing for polygenic risk (PGT-P)—uses polygenic indexes (PGIs) to predict the expected value of the phenotype(s) that would arise for each embryo if successfully transferred; parents can use these predictions to select an embryo for in vitro fertilization (IVF). Seeing gaps in evidence and analysis relevant for potential policy discussions around PGT-P, we conducted a survey of public attitudes. Our data suggest that it would be unwise to assume that use of PGT-P—even for controversial traits—will be limited to idiosyncratic individuals, or that it has little potential to cause or contribute to society-wide changes and inequities."[/FONT]
 

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